Project Deliverables

Work Package 1

D1.1 - Governance report

D1.2 - Quality assurance plan

D1.3 - Project Data Management Plan (P-DMP)

D1.4 - Risk assessment reports

D1.5 - Project Data Management Plan Update

Work Package 2

D2.1 - Research-Data Management Plan (R-DMP)

D2.2 - VASC Submission package

D2.3 - Curated datasets

D2.4 - Annotated CMR data

D2.5 - VASC Mid-term recruitment report

D2.6 - VASC Report on the status of the posting of results to the registry

Work Package 3

D3.1 -Delivery of existing single iPSC cardiomyocyte measurement data

D3.2 - Generated and shared cardiomyocytes

D3.3 - Novel platform for rapid pharmacological evaluations

Work Package 4

D4.1 - Libraries of HCM populations of cellular electromechanical models

D4.2 - Technologies for optimal therapy choice

D4.3 - Integration of biophysical modelling technologies

D4.4 - Pipeline personalization of human heart electromechanical models

D4.5 - Technologies for personalized optimal therapy choice

Work Package 5

D5.1 - HCM populations of smooth muscle cell models

D5.2 - Integration of vascular biophysical multiorgan modeling technologies

D5.3 - Personalization of multiorgan models

D5.4 -Technologies for prognostics of personalized optimal therapy choice

Work Package 6

D6.1 - Requirements SMASH-HCM predictive/clustering tool

D6.2 - Initial Evidence-based models and biomarkers

D6.3 - Interpretable referral models for clinical use

D6.4 - Initial Data-driven models

D6.5 - Predictive/stratification tools in HCM and related conditions

D6.6 - Validation results of HCM risk stratification models

Work Package 7

D7.1 - Requirements SMASH-HCM solution in clinical practice – initial

D7.2 - Requirements for disease patients' self-management

D7.3 - Design specifications of an API for DSS algorithms

D7.4 - API for DSS algorithms

D7.5 - Integrated DSS for HCM stratification and disease management – initial

D7.6 - SMASH-HCM solution as research tool requirements

D7.7 - SMASH-HCM requirements in clinical practice - final

D7.8 - Integrated DSS for HCM stratification and disease management - final

D7.9 - DSS software package for continued research

Work Package 8

D8.1 - Ethical approval of the whole SMASH-HCM study

D8.2 - Patient organizations discussions and feedback

D8.3 - Clinical data use contracts: hospitals and universities

D8.4 - Contact with regulatory agencies FIMEA, DEKRA

D8.5 - PILOT Submission package

D8.6 - EU Clinical Trials Register

D8.7 - Ethical approval for the pilot study

D8.8 - Discussion with ESC HCM subgroup

D8.9 - Collaboration agreement pharmaceutical and technological industry

D8.10 - PILOT Mid-term recruitment report

D8.11 - Requirements and guidelines for health techology assessment and health economics

D8.12 - PILOT Report on the status of the posting of results to the registry

Work Package 9

D9.1 - Dissemination, communication and exploitation plan

D9.2 - Project Website

D9.3 - Socio-economic impact assessment framework

D9.4 - Updated dissemination, communication and exploitation plan

D9.5 - Exploitation & business plan

D9.6 - Final business model planning

D9.7 - Dissemination and communication report