Last year, was very productive for SMASH-HCM as we have made significant progress in the project. Our SMASH-HCM members presented preliminary results at multiple conferences, published several papers, and shared key insights with the community. A huge congratulations to them!
Below is a showcase of selected highlights:
In November 2025 Marion Taconné, from our project partner Politecnico di Milano, attended the European Society of Cardiology Digital & AI Summit in Berlin. She presented a poster on “A New 5-Year Risk Score for Hypertrophic Cardiomyopathy: Integrating Echocardiography, Clinical, and ECG Data”. The result of their study provides a new risk score predictor for Hypertrophic Cardiomyopathy (HCM) patients based on classical parameters extracted from echocardiography, clinical information, and medication. They also studied the evolution of this new risk score through the years. The risk predictor was created with the help of Machine Learning models trained on Florence data.
In December, Adrien Al Wazzan presented on “Clustering analysis of left atrial strain for risk assessment in hypertrophic cardiomyopathy” at EACV in Vienna. The presentation focussed on the development of a new methodology for extracting parameters from left atrial deformation curves and their evaluation for the stratification of the risk of adverse events in patients with hypertrophic cardiomyopathy. The work is conducted by the Laboratoire du traitement du signal et de l’image in collaboration with Francesca Menna and is based on a cohort of patients follow-up at the Rennes University Hospital.
James Coleman, Alfonso Bueno-Orovio, and Abdalah Hasaballa recently published their article “Simulation-based digital twinning of activation and repolarisation sequences from the ECG across healthy and diseased hearts” in Computers in Biology and Medicine. The article presents new methods that allow us to reconstruct ventricular electrical function from a 12-lead ECG. In the future this will be applied to map the electrophysiology of HCM hearts. James had previously presented these findings at the Fickle Heart workshop in Sheffield in September.
We are looking forward to an equally productive year 2026!