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University of Oxford

The Computational Cardiovascular Science group at the University of Oxford aims at the combination of computational methods in cardiovascular research to integrate and expand the information extracted from a range of experimental and clinical data, including biosignals and medical images.

Role in the project

In the SMASH-HCM project, we lead Work Package 4 (WP4) on “Validated in-silico cardiac models”, where our main responsibilities encompass the development of cardiac digital twin models of human heart function. Additionally, we contribute to WP5, aiming at the integration of multi-scale vascular and multi-organ modelling; to WP6, aiming at data-driven modelling and integration; and to WP8, for the clinical, patient, and social uptake of the SMASH-HCM Digital Twin system. Our involvement is crucial for the development of novel technologies to investigate risk stratification and tailoring of pharmacological therapy in hypertrophic cardiomyopathy patients, emphasising our commitment to the clinical and industrial translation of Computational Medicine.

Colleagues working on the project

uoxf alfonso bueno orovio

Alfonso Bueno-Orovio

Prof, PhD
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His research is in the field of Computational Medicine, with a focus on Mathematical Modelling and Simulation, Scientific Computing, and applications of Machine Learning. His main research area is in Cardiovascular Research, to investigate mechanisms of disease, risk stratification of patients, personalisation of therapy, discovery of new therapeutic targets, and the safety and efficacy of treatments, with a focus on the clinical and industrial translation of Computational Medicine. His main research interest is in the field of inherited cardiomyopathies, with especial attention to Hypertrophic Cardiomyopathy.

Prior to his current tenure-track position at Oxford, Professor Alfonso Bueno-Orovio has been the recipient of a British Heart Foundation Research Fellowship on Basic Science, and he has received research grants from multiple funders throughout his career, including the EPSRC, the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), and the European Union. His research has been awarded best paper prizes from the USA Society for Industrial and Applied Mathematics, NC3Rs, Safety Pharmacology Society, and at conference venues such us Computing in Cardiology, Functional Imaging and Modelling of the Heart, or Medical Image Computing and Computer Assisted Intervention. He is a member of the editorial board of Frontiers in Physiology, Frontiers in Bioengineering and Biotechnology, and Mathematics.

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